Glutathione and Post-Inflammatory Hyperpigmentation (PIH): Emerging Treatment Approaches Explained
I f you’ve ever had a pimple heal but leave behind a stubborn dark mark that refuses to fade for months, you’ve already experienced post-inflammatory hyperpigmentation (PIH). And honestly, this is where many people get frustrated because the acne disappears, but the pigmentation stays longer than the breakout itself. Dermatologists today are starting to explain PIH a little differently than before. Instead of seeing it as just a surface skin problem , research now shows it’s strongly connected to inflammation and oxidative stress happening inside the skin cells. Let’s break this down in a simple way. Why Acne Marks and Sun Damage Turn Dark Think of your skin like a protection system. Whenever it experiences injury like acne, irritation, burns, aggressive treatments, or even excessive sun exposure your body activates defense signals. These signals release inflammatory chemicals that tell pigment-producing cells (melanocytes) to produce more melanin. The problem? Sometimes the skin ...